A new drug-free anti-platelet therapy which is reversible could lower
the risk of clotting in blood and potentially prevent cancer metastasis. A study reported in Science Translational Medicine reveals that this
therapeutic approach involves modification of human platelets to create
"decoys" which are still capable of binding to some cells but will
not mix-up or carry out the other regular platelet functions, including
chemical signaling associated with the coagulation process.
Platelets play a crucial role in resisting the bleeding and help to
protect against life-threatening bleeding. Even though the hyperactive
platelets are able to contribute various disorders, including severe blood clots,
heart disease and cancer, several anti-platelet drugs inhibits clotting and their effects are not easy to reverse the
function, leaving patients in dangerous condition if they develop unexpected
severe bleeding or are in need of an emergency surgical procedure. Platelets also play an important role in cancer metastasis by binding to cancer cells and protecting them from the body's immune system and shear
stress due to their circulations in the bloodstream. Platelets may also help the cancer
cells to get rid from the way of blood vessels and seed distant tissues during the process of
metastasis.
These studies will be available with the cancer pharmacology studies and the insights of cancer pharmacology and the pharmaceutical aids towards the blood clots are anti-platelet drugs like Aspirin, dipyridamole, cilostazol.
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