How to treat Heart Diseases?

mTOR, a protein receives signals from cell division process through internal sensors that measures nutrients and energy supply and directs the cell to take action. These molecular switch studies were applied on heart disorders like overworked heart (enlarging).  It is also have applications in diabetes, kidney and lung disease, cancer and autoimmune disorders.

The protein mTOR, stands for mechanistic target of rapamycin, is so important to normal cells yet also plays major roles in several diseases. It combines with other proteins to form a complex, the major one being known as mTORC1. Superiorly active mTORC1 is known to be bad for the heart and leads to damage and disease, and it is thought that having control over mTORC1 protein could effectively treat heart disease. Overworked hearts with too much active mTORC1 enlarge abnormally similar to body muscle that bulks up after carrying heavy weights.

There is another protein called Protein Kinase G, which protects heart tissue from damage and disease. The surprising discovery of scientists’ that is the protein kinase G blocked mTORC1, figured out the key regulator of mTORC1 called tuberin (dubbed TCS2 by researchers), which acts like an "antenna" for biochemical signals triggering or blocking cell growth, and regulating metabolism. Similar to many other proteins known to alter tuberin, Ranek found protein kinase G altered tuberin by adding phosphates to it, but in a previously unpredicted region that turned out to provide the sought after brake-like effect. Protein kinase G is also the target of drugs like sildenafil which is commonly known as Viagra.