World Rare Diseases Awareness Day-February 28, 2019

Rare diseases are those who attacks very number of population. They may occur from genetic transformations and travels through out their life in them. According to the symptoms we can diagnose the disease, but the symptoms and signs are also very rare and also varies from disease to diseases and person to person. 

In Europe, it is said to be a rare disease if it affects 1 in 2000 people. Rare diseases also affects the family, friends and neighbors along with the diagnosed person. However it said to be rare in Europe 30 million people are diagnosed with almost 6000 different diseases which are all rare. 

List of some Rare Diseases

Adams Oliver Syndrome

African Iron Overload

Acquired Aplastic Anemia

Aceruloplasminemia

Ameloblastic Carcinoma

Ulcerative Colitis

Scleroderma

Turner Syndrome

Thyroid Cancer

Syphilis, Acquired

Spondylocostal Dysplasia

Wolff Parkinson White Syndrome

Tuberculosis

Xeroderma Pigmentosum

Visual Snow Syndrome

Yellow Fever

Yellow Nail syndrome

Zollinger-Ellison Syndrome

How to treat Heart Diseases?

mTOR, a protein receives signals from cell division process through internal sensors that measures nutrients and energy supply and directs the cell to take action. These molecular switch studies were applied on heart disorders like overworked heart (enlarging).  It is also have applications in diabetes, kidney and lung disease, cancer and autoimmune disorders.

The protein mTOR, stands for mechanistic target of rapamycin, is so important to normal cells yet also plays major roles in several diseases. It combines with other proteins to form a complex, the major one being known as mTORC1. Superiorly active mTORC1 is known to be bad for the heart and leads to damage and disease, and it is thought that having control over mTORC1 protein could effectively treat heart disease. Overworked hearts with too much active mTORC1 enlarge abnormally similar to body muscle that bulks up after carrying heavy weights.

There is another protein called Protein Kinase G, which protects heart tissue from damage and disease. The surprising discovery of scientists’ that is the protein kinase G blocked mTORC1, figured out the key regulator of mTORC1 called tuberin (dubbed TCS2 by researchers), which acts like an "antenna" for biochemical signals triggering or blocking cell growth, and regulating metabolism. Similar to many other proteins known to alter tuberin, Ranek found protein kinase G altered tuberin by adding phosphates to it, but in a previously unpredicted region that turned out to provide the sought after brake-like effect. Protein kinase G is also the target of drugs like sildenafil which is commonly known as Viagra.